Education

Emory University School of Medicine

 2009-2012; Postdoctoral Fellow

University of Maryland at College Park

 2004-2009; Ph.D. Immunology

Academic Experience

Full Professor & Associate Director

Institute of Immunology, Third Military Medical University                                                   

2013-Present

Overview of Academic Research

T cell mediated immune responses to acute/chronic viral infection and cancer;

Vaccinology

Major Honor and Awards

China Qiushi Award, 2021                                                                            

Wuxi Apptech Award Life Science, 2016                                   

Scientist in Chief, National Key Research and Development Plan, 2012            

Representative Research Achievements

He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H*, Wu Y*, Ye L*. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection. Nature. 2016 Aug 2;537(7620):412-428. doi: 10.1038/nature19317.

Xu L, Cao Y, Xie Z, Huang Q, Bai Q, Yang X, He R, Hao Y, Wang H, Zhao T, Fan Z, Qin A, Ye J, Zhou X*, Ye L*, Wu Y*.The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection.Nat Immunol. 2015 Sep;16(9):991-9. doi: 10.1038/ni.3229. Epub 2015 Jul 27.

Xu L, Huang Q, Wang H, Hao Y, Bai Q, Hu J, Li Y, Wang P, Chen X, He R, Li B, Yang X, Zhao T, Zhang Y, Wang Y, Ou J, Liang H, Wu Y, Zhou X, Ye L*. The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells. Immunity. 2017 Sep 19;47(3):538-551.e5. doi: 10.1016/j.immuni.2017.08.011.

Zhao L, He R, Long H, Guo B, Jia Q, Tan Y, Xiang T, Zhang J, Hu C, Gao J, Yang X, Zeng H, Wang X, Huang J, Symonds A,LJ, , Wan Y, Li Q*, Ye L*, Zhu B*. CD45+CD71+TER119+ erythroid progenitor cells derived from tumor-bearing hosts suppress the CD8+ T cell response via the ROS pathway. Nat Medicine. 2018. 24:1536-1544.

Wang Y, Tian Q, Hao Y, Yao W, Lu J, Chen C, Chen X, Lin Y, Huang Q, Xu L, Hu J, Lei S, Wei Z, Luo Y, Li Z, Hu L, Tang J, Wu Q, Zhou X, Wu Y, Yin Z*, Xu J*, Ye L*. The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis. Nat Immunol. 2022 Feb;23(2):303-317. doi: 10.1038/s41590-021-01090-1. Epub 2021 Dec 23.

Huang Q, Wu X, Wang Z, Chen X, Wang L, Lu Y, Xiong D, Liu Q, Tian Y, Lin H, Guo J, Wen S, Dong W, Yang X, Yuan Y, Yue Z, Lei S, Wu Q, Ran L, Xie L, Wang Y, Gao L, Tian Q, Zhou X, Sun B*, Xu L*, Tang Z*, Ye L*.The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes.Cell. 2022 Oct 4:S0092-8674(22)01192-8. doi: 10.1016/j.cell.2022.09.020.

Liang Y*, Ye L*.Bound to be perfect: Lck and T cell co-receptors. Nat Immunol. 2023 Jan;24(1):5-7. doi: 10.1038/s41590-022-01392-y.